Reply to Paranhos-Baccalà et al. Comment on "Cuesta et al. An Assessment of a New Rapid Multiplex PCR Assay for the Diagnosis of Meningoencephalitis. Diagnostics 2024, 14 , 802".

This document is a reply to a comment made by Paranhos-Baccalà et al. regarding a recent article published in the journal Diagnostics. The authors of the reply acknowledge the sensitivity controversy surrounding the Biofire Filmarray ME panel, specifically in relation to HSV-1. They discuss the limitations of their study and address concerns raised by Paranhos-Baccalà et al. regarding the representativeness of the samples studied. The authors emphasize the importance of clinical correlation in the diagnosis of meningoencephalitis and suggest that larger comparative studies are needed to confirm their findings. [Extracted from the article]