Response to Letter to the Editor From de Zegher and Ibáñez: "Adipose Tissue Dysfunction in Polycystic Ovary Syndrome".

The article is a response to a letter from Drs. de Zegher and Ibáñez regarding the role of adipose tissue dysfunction in polycystic ovary syndrome (PCOS). The authors of the response agree with the doctors' belief that dysfunctional adipose tissue is central to PCOS and contributes to hyperinsulinemia and ectopic fat accumulation. They explain that their review focused on the mechanisms of adipose tissue dysfunction and did not extensively cover therapeutic options for managing PCOS. They also discuss the limitations of oral contraceptives in treating PCOS and the potential benefits of combination therapy with flutamide, metformin, and pioglitazone. The authors caution against prematurely extrapolating the results of studies on spironolactone and suggest that more research is needed to understand its role in modulating adipose tissue. They conclude by emphasizing the importance of addressing adipose tissue dysfunction in PCOS and the need for further studies on the effects of various medications on this dysfunction. [Extracted from the article]