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Solving genomic puzzles: computational methods for metagenomic binning.

Authors :
Mallawaarachchi, Vijini
Wickramarachchi, Anuradha
Xue, Hansheng
Papudeshi, Bhavya
Grigson, Susanna R
Bouras, George
Prahl, Rosa E
Kaphle, Anubhav
Verich, Andrey
Talamantes-Becerra, Berenice
Dinsdale, Elizabeth A
Edwards, Robert A
Source :
Briefings in Bioinformatics; Sep2024, Vol. 25 Issue 5, p1-17, 17p
Publication Year :
2024

Abstract

Metagenomics involves the study of genetic material obtained directly from communities of microorganisms living in natural environments. The field of metagenomics has provided valuable insights into the structure, diversity and ecology of microbial communities. Once an environmental sample is sequenced and processed, metagenomic binning clusters the sequences into bins representing different taxonomic groups such as species, genera, or higher levels. Several computational tools have been developed to automate the process of metagenomic binning. These tools have enabled the recovery of novel draft genomes of microorganisms allowing us to study their behaviors and functions within microbial communities. This review classifies and analyzes different approaches of metagenomic binning and different refinement, visualization, and evaluation techniques used by these methods. Furthermore, the review highlights the current challenges and areas of improvement present within the field of research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14675463
Volume :
25
Issue :
5
Database :
Complementary Index
Journal :
Briefings in Bioinformatics
Publication Type :
Academic Journal
Accession number :
179874077
Full Text :
https://doi.org/10.1093/bib/bbae372