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Intraparticle Electron Transfer for Long‐Lasting Tumor Chemodynamic Therapy.

Authors :
Yu, Jing
Yan, Hongmeng
Zhao, Fan
Ying, Yao
Li, Wangchang
Li, Juan
Zheng, Jingwu
Qiao, Liang
Yang, Wei
Che, Shenglei
Source :
Advanced Science; 9/25/2024, Vol. 11 Issue 36, p1-13, 13p
Publication Year :
2024

Abstract

Chemodynamic therapy (CDT) is a novel tumor treatment method by using hydroxyl radicals (•OH) to kill cancer cells. However, its therapeutic effects are strictly confined by the short lifespan of •OH and reduced •OH generation speed. Herein, an effective CDT is achieved by both improving •OH lifetime and long‐lasting generating •OH through intraparticle electron transfer within heterogeneous nanoparticles (NPs). These heterogeneous NPs are composed of evenly distributed Cu and Fe3O4 (CFO NPs) with large interaction interfaces, and electrons tend to transfer from Cu to Fe3O4 for the appearance of ≡Cu2+ and increase in ≡Fe2+. The generated ≡Cu2+ can interact with GSH, which prolongs the lifespan of •OH, produces ≡Cu+ for higher speed •OH generation with H2O2, and induces cell ferroptosis for tumor therapy. The improved ≡Fe2+ can also improve the •OH release under H2O2 until Cu is depleted. As a result, a sustainable •OH generation is achieved to promote cell apoptosis for effective tumor therapy. Since H2O2 and GSH are only overexpressed at tumor, and CFO NPs can degrade in the tumor microenvironment, these NPs are with high biosafety and can be metabolized by urine. This work provides a novel biomaterial for effective cancer CDT through intraparticle electron transfer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
21983844
Volume :
11
Issue :
36
Database :
Complementary Index
Journal :
Advanced Science
Publication Type :
Academic Journal
Accession number :
179878476
Full Text :
https://doi.org/10.1002/advs.202403935