Investigators from Department of Chemistry Zero in on Tuberculosis [Investigation of Novel 2-(Chloromethyl)-5-(3, 5-disubstituted-1h-indol-2-yl)-1,3,4-oxadiazole Derivatives As In Vitro, and In Silico Bioactivity Potential: Anti-inflammatory,...].

A recent study conducted in Karnataka, India, focused on the synthesis of novel compounds with potential anti-inflammatory, anti-TB, and antioxidant activities. The compounds were evaluated for their physicochemical properties, ADME, and drug-likeness profile. Some of the synthesized compounds showed promising COX-II inhibitory activity, anti-TB activity, and antioxidant activity. Molecular docking studies were also conducted to further investigate the compounds. This research provides valuable insights into the development of potential treatments for tuberculosis. [Extracted from the article]