Research Conducted at Netherlands Cancer Institute Has Updated Our Knowledge about Small Cell Lung Cancer (Osimertinib-induced Dna Resistance Mutations In Cerebrospinal Fluid of Epidermal Growth Factor Receptor-mutated Non-small-cell Lung...).

A recent study conducted at the Netherlands Cancer Institute has provided new insights into small cell lung cancer. The study focused on the diagnosis and treatment of leptomeningeal metastases (LM) in patients with epidermal growth factor receptor mutation-positive (EGFRm +) non-small-cell lung carcinoma (NSCLC). The researchers aimed to identify resistance mechanisms (RM) to osimertinib in cerebrospinal fluid (CSF) and plasma. The study found that 27% of patients had an RM in CSF ctDNA, and the clinical efficacy of osimertinib dose escalation (DE) was limited. The researchers concluded that there is still much to learn about diagnostic and therapeutic strategies for EGFRm + NSCLC LM. [Extracted from the article]