Analysis of Differential Sweat Metabolites and Related Pathways in Patients with Atopic Dermatitis Characterized by Heart Fire and Spleen Deficiency Syndrome.

Objective To investigate the differential sweat metabolites and related pathways in patients with atopic dermatitis (AD) characterized by heart fire and spleen deficiency syndrome. Methods Twenty-two AD patients with heart fire and spleen deficiency syndrome and 22 healthy volunteers were recruited. Extensive targeted metabolomics analysis was conducted on collected sweat samples, and differential metabolites were identified through multivariate statistical analysis. The KEGG databases and HMDB were utilized to analyze the related pathways and associated diseases of the differential metabolites. Results A total of 115 differential metabolites were identified between the two groups of sweat samples. According to the KEGG database annotation analysis, these metabolites were involved in 15 different pathways. The HMDB's disease association analysis suggested a close relationship with digestive system diseases, including colorectal cancer, eosinophilic esophagitis, Crohn's disease, and ulcerative colitis. Conclusion There are numerous differential metabolites between AD patients with heart fire and spleen deficiency syndrome and the healthy control group, which may provide clues for the early warning of comorbidities in clinical practice. [ABSTRACT FROM AUTHOR]