Combined Genome-Wide Association Study and Haplotype Analysis Identifies Candidate Genes Affecting Growth Traits of Inner Mongolian Cashmere Goats.

Simple Summary: Inner Mongolian cashmere goats (IMCGs) are an excellent local breed that formed due to natural selection and artificial breeding over a long time, and they are a world-class breed used for both cashmere and meat consumption. Growth traits are the key indicators of cashmere goats' growth, development, and health. Therefore, in this study, based on resequencing data (20×), the molecular markers and candidate genes affecting the growth traits of Inner Mongolian cashmere goats (Erlangshan type) were identified through a genome-wide association study combined with haplotype analysis. In this study, genome-wide association analysis was performed on the growth traits (body height, body length, chest circumference, chest depth, chest width, tube circumference, and body weight) of Inner Mongolian cashmere goats (Erlangshan type) based on resequencing data. The population genetic parameters were estimated, haplotypes were constructed for the significant sites, and association analysis was conducted between the haplotypes and phenotypes. A total of two hundred and eighty-four SNPs and eight candidate genes were identified by genome-wide association analysis, gene annotation, and enrichment analysis. The phenotypes of 16 haplotype combinations were significantly different by haplotype analysis. Combined with the above results, the TGFB2, BAG3, ZEB2, KCNJ12, MIF, MAP2K3, HACD3, and MEGF11 functional candidate genes and the haplotype combinations A2A2, C2C2, E2E2, F2F2, I2I2, J2J2, K2K2, N2N2, O2O2, P2P2, R1R1, T1T1, W1W1, X1X1, Y1Y1, and Z1Z1 affected the growth traits of the cashmere goats and could be used as molecular markers to improve the accuracy of early selection and the economic benefits of breeding. [ABSTRACT FROM AUTHOR]