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Serological Outcome in the First Months of Life of Children Born to Mothers with SARS-CoV-2 Infection during Pregnancy.
- Source :
- Children; Sep2024, Vol. 11 Issue 9, p1095, 13p
- Publication Year :
- 2024
-
Abstract
- Background: The objective of this study is to analyze the transplacental transmission of SARS-CoV-2 antibodies, their persistence in newborns, the factors that may influence this transmission, and the protection these antibodies confer over time. Methods: This prospective cohort was conducted in a tertiary pediatric hospital in the Barcelona Metropolitan Region, Spain. It included neonates born to mothers who had SARS-CoV-2 infection during pregnancy or delivery between August 2020 and January 2022. We followed the recruited children for at least six months, and blood tests were performed to determine the presence of SARS-CoV-2 antibodies. Results: A total of 101 children were recruited. Among the serologies performed on children under three months of age, 44/82 were positive (53.7%). Newborns whose mothers presented more severe disease exhibited higher seropositivity odds (coefficient 9.747; p = 0.002). There were increased preterm deliveries when maternal infection occurred closer to the time of delivery. No severe SARS-CoV-2 infections were detected in children during the follow-up. Conclusions: Slightly more than half of the SARS-CoV-2 serologies performed in the first three months were positive. This appears to confer protection during early childhood. The severity of maternal infection is the most significant factor influencing the transmission of antibodies in children born to unvaccinated mothers. [ABSTRACT FROM AUTHOR]
- Subjects :
- RNA analysis
RISK assessment
STATISTICAL models
RESEARCH funding
BLOOD testing
PATIENTS
IMMUNOGLOBULINS
LOGISTIC regression analysis
PREMATURE infants
POLYMERASE chain reaction
HOSPITAL admission & discharge
TERTIARY care
CHILDREN'S hospitals
SEVERITY of illness index
COVID-19 vaccines
DESCRIPTIVE statistics
LONGITUDINAL method
ODDS ratio
VOLUMETRIC analysis
VERTICAL transmission (Communicable diseases)
RESEARCH
MEDICAL records
BIRTH weight
SEROPREVALENCE
CLINICS
IMMUNOASSAY
DATA analysis software
SERODIAGNOSIS
COVID-19
PATIENT aftercare
REGRESSION analysis
TIME
VACCINATION status
PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 22279067
- Volume :
- 11
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Children
- Publication Type :
- Academic Journal
- Accession number :
- 180018015
- Full Text :
- https://doi.org/10.3390/children11091095