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Sex Differences and Bmal1/Acetylcholine- or Bmal1/Noradrenaline-Mediated Effects of Blue Light Irradiation on Dextran-Sodium-Sulfate-Induced Ulcerative Colitis Model Mice.
- Source :
- Gastrointestinal Disorders; Sep2024, Vol. 6 Issue 3, p720-732, 13p
- Publication Year :
- 2024
-
Abstract
- Humans are exposed to significant amounts of blue light from computers and smartphones. However, the effects of blue light on ulcerative colitis remain unclear. In this study, we assessed blue-light-irradiation-induced alterations in colonic symptoms using a dextran sodium sulfate (DSS)-induced ulcerative colitis model mice. Both male and female institute of cancer research (ICR) mice were administered DSS (5%) ad libitum for 5 days while irradiated with 40 kJ/m<superscript>2</superscript> blue light daily. Additionally, tranexamic acid (TA) was administered daily throughout the study. Male mice treated with DSS/blue light exhibited exacerbated colitis compared to those treated with DSS alone. In contrast, female mice treated with DSS/blue light exhibited enhanced symptoms compared to those treated with DSS alone. Additionally, in male mice exposed to blue light, the clock/brain and muscle Arndt-like 1 (Bma1)/noradrenaline/macrophage or beta2-adrenergic receptor (β2-AR) pathways were activated. In female mice, the Bmal1/acetylcholine/macrophage/nicotinic acetylcholine receptor alpha 7 (α7nAChR) pathway was activated. These findings highlight sex differences in the effects of blue light on DSS-induced ulcerative colitis. Moreover, the worsening of symptoms in males was ameliorated through TA administration. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 26245647
- Volume :
- 6
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Gastrointestinal Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 180020404
- Full Text :
- https://doi.org/10.3390/gidisord6030048