Bronchial Remodeling Identifies New Endotypes in Severe Preschool Wheezers.

This article presents the findings of a study on bronchial remodeling in preschool children with severe preschool wheezing (SPW). The study identified two distinct classes of SPWs, BR1 and BR2, based on bronchial remodeling characteristics. These classes had different disease trajectories, clinical manifestations, and treatment responses. The study suggests that quantifying and targeting multiple bronchial remodeling features can help identify and monitor these two endotypes of SPWs. The article also emphasizes the need for biomarkers and genetic characteristics to easily identify these endotypes. [Extracted from the article]