The curious immune cells caught between worlds.

This article discusses the role of innate-like T cells in the immune system and their potential for developing new immunotherapies against diseases like cancer. The researchers, led by Assistant Professor Hannah Meyer from Cold Spring Harbor Laboratory, found that innate-like T cells mature differently in humans than in mice, with age playing a critical role. They discovered that early in life, these cells are not able to use all of their immune abilities, but in adults, they are ready to fight as soon as they receive the signal. The researchers believe that these differences should be considered when developing and testing immunotherapeutics, as much of the research is currently conducted in mouse models. [Extracted from the article]