Findings from National Institute of Alcohol Abuse and Alcoholism Provide New Insights into Liver Fibrosis (Melatonin Prevents Thioacetamide-induced Gut Leakiness and Liver Fibrosis Through the Gut-liver Axis Via Modulating Sirt1-related...).

A recent study conducted by researchers at the National Institute of Alcohol Abuse and Alcoholism in Bethesda, Maryland, has found that melatonin, a well-known antioxidant and anti-inflammatory agent, may have protective effects against liver fibrosis. The study focused on the mechanisms by which melatonin prevents gut leakiness and liver fibrosis through the gut-liver axis by attenuating the acetylation of intestinal and hepatic proteins. The findings suggest that melatonin consumption could potentially be a safe supplement for liver fibrosis patients by preventing protein hyper-acetylation and gut leakiness. This research has been peer-reviewed and published in the Journal of Pineal Research. [Extracted from the article]