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Prognostic Role of Pre-Treatment Body Composition Parameters in Patients Undergoing First-Line Immunotherapy for Metastatic Renal Cell Carcinoma.

Authors :
Lee, Sangmin
Kim, Jae-Hun
Song, Wan
Sung, Hyun Hwan
Jeon, Hwang Gyun
Jeong, Byong Chang
Seo, Seong Il
Jeon, Seong Soo
Park, Se Hoon
Lee, Ji Hyun
Yu, Jiwoong
Kang, Minyong
Source :
Cancer Management & Research; Aug2024, Vol. 16, p1091-1101, 11p
Publication Year :
2024

Abstract

Purpose: We investigated the relationship between body mass index (BMI), radiological body composition, and survival outcomes in patients with metastatic renal cell carcinoma (mRCC) underwent first-line immune checkpoint inhibitor (ICI)-based therapy. Methods: Analyzing data from 102 patients treated between November 2019 and March 2023, pre-treatment computed tomography (CT) scans assessed fat and muscle areas. BMI and body composition indices were examined, including skeletal muscle index, subcutaneous fat index (SFI), visceral fat index, and total fat index. Kaplan–Meier curves and Log rank tests compared progression-free survival (PFS) and overall survival (OS), while multivariable Cox proportional regression analysis was performed to identify the variables significantly associated with survival outcomes. Results: 54 patients (52.9%) experienced disease progression, and 26 (25.5%) died during a median follow-up of 17.4 months. High SFI was significantly associated with improved OS (p = 0.018) but not PFS (p = 0.090). Multivariable analysis confirmed the positive impact of high SFI on OS (adjusted HR: 0.37, p = 0.029) and suggested a trend towards improved PFS (adjusted HR: 0.61, p = 0.088). Notably, in the ipilimumab + nivolumab subgroup, high SFI significantly correlated with both PFS and OS (p = 0.047 and p = 0.012, respectively). Conclusion: High SFI predicts favorable OS in patients with mRCC receiving first-line ICI-based therapy, especially patients treated with ipilimumab + nivolumab displayed a significant association between high SFI and favorable PFS and OS. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11791322
Volume :
16
Database :
Complementary Index
Journal :
Cancer Management & Research
Publication Type :
Academic Journal
Accession number :
180096040
Full Text :
https://doi.org/10.2147/CMAR.S476150