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Advancing therapeutic efficacy: nanovesicular delivery systems for medicinal plant-based therapeutics.

Authors :
Saadh, Mohamed J.
Mustafa, Mohammed Ahmed
Kumar, Sanjay
Gupta, Pooja
Pramanik, Atreyi
Rizaev, Jasur Alimdjanovich
Shareef, Hasanain Khaleel
Alubiady, Mahmood Hasen Shuhata
Al-Abdeen, Salah Hassan Zain
Shakier, Hussein Ghafel
Alaraj, Mohd
Alzubaidi, Laith H.
Source :
Naunyn-Schmiedeberg's Archives of Pharmacology; Oct2024, Vol. 397 Issue 10, p7229-7254, 26p
Publication Year :
2024

Abstract

The utilization of medicinal plant extracts in therapeutics has been hindered by various challenges, including poor bioavailability and stability issues. Nanovesicular delivery systems have emerged as promising tools to overcome these limitations by enhancing the solubility, bioavailability, and targeted delivery of bioactive compounds from medicinal plants. This review explores the applications of nanovesicular delivery systems in antibacterial and anticancer therapeutics using medicinal plant extracts. We provide an overview of the bioactive compounds present in medicinal plants and their therapeutic properties, emphasizing the challenges associated with their utilization. Various types of nanovesicular delivery systems, including liposomes, niosomes, ethosomes, and solid lipid nanoparticles, among others, are discussed in detail, along with their potential applications in combating bacterial infections and cancer. The review highlights specific examples of antibacterial and anticancer activities demonstrated by these delivery systems against a range of pathogens and cancer types. Furthermore, we address the challenges and limitations associated with the scale-up, stability, toxicity, and regulatory considerations of nanovesicular delivery systems. Finally, future perspectives are outlined, focusing on emerging technologies, integration with personalized medicine, and potential collaborations to drive forward research in this field. Overall, this review underscores the potential of nanovesicular delivery systems for enhancing the therapeutic efficacy of medicinal plant extracts in antibacterial and anticancer applications, while identifying avenues for further research and development. The role of nanovesicular delivery systems in enhancing the therapeutic potential of medicinal plant extracts against bacterial infections and cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00281298
Volume :
397
Issue :
10
Database :
Complementary Index
Journal :
Naunyn-Schmiedeberg's Archives of Pharmacology
Publication Type :
Academic Journal
Accession number :
180107086
Full Text :
https://doi.org/10.1007/s00210-024-03104-9