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Study Findings on Protein Engineering Are Outlined in Reports from Beijing University of Chemical Technology (Why Insulin Aspart and Insulin Degludec Exhibit Distinct Release Mechanisms).

Source :
Drug Week; 10/18/2024, p3271-3271, 1p
Publication Year :
2024

Abstract

A study conducted by researchers at Beijing University of Chemical Technology explores the molecular mechanisms underlying insulin analogs, specifically insulin aspart (IAsp) and insulin degludec (IDeg). These insulin analogs have distinct release profiles and are synthesized through targeted mutagenesis in protein engineering. The study utilizes molecular dynamics simulation and experimental verification to investigate the structural stability, solubility analysis, and monomer interactions of these insulins, providing insights into the differences in their release mechanisms. The findings shed light on the intricate mechanisms underlying insulin release and have potential implications for the design of insulin therapy. [Extracted from the article]

Details

Language :
English
ISSN :
15316440
Database :
Complementary Index
Journal :
Drug Week
Publication Type :
Periodical
Accession number :
180201266