Investigators at University of Nevada Detail Findings in Life Science (Mitochondrial Ca2+-coupled Generation of Reactive Oxygen Species, Peroxynitrite Formation, and Endothelial Dysfunction In Cantu Syndrome).

A recent report from the University of Nevada discusses the findings of a study on Cantú syndrome, a multisystem disorder caused by specific genetic mutations. The researchers investigated changes in the vascular endothelium in mice with these mutations and found that endothelium-dependent dilation was impaired, leading to increased vasoconstriction. They also observed increased cytosolic calcium signaling activity, mitochondrial calcium overload, and elevated reactive oxygen species and peroxynitrite levels in arterial endothelial cells from mice with Cantú syndrome. The researchers concluded that these factors contribute to endothelial dysfunction in individuals with Cantú syndrome. This research was supported by various organizations, including the NIH and the Universidad de la Republica. [Extracted from the article]