University of New England Researcher Discusses Research in Streptococcal Infections (Mechanisms that potentially contribute to the development of post-streptococcal glomerulonephritis).

A recent study conducted by researchers at the University of New England explores the mechanisms that potentially contribute to the development of post-streptococcal glomerulonephritis (PSGN). PSGN is primarily associated with preceding Group A streptococcal skin or throat infections, particularly in economically disadvantaged communities. The study suggests that streptococcal pyrogenic exotoxin B and nephritis-associated plasmin receptor are identified as nephritogenic antigens, and the pathogenesis of PSGN is multifactorial. However, further investigation is needed to understand the interplay between streptococcal antigens and the disease process. The lack of credible animal models poses challenges in this area of research. The study provides an overview of the postulated mechanisms involved in the development of PSGN and potential therapeutic approaches. [Extracted from the article]