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Recent Progress in Generation of Inner Ear Organoid.

Authors :
Zong, Yanjun
Liu, Xiaozhou
Zhang, Yaqi
Zhao, Jiahui
Shi, Xinyu
Zhao, Zhengdong
Sun, Yu
Source :
Advanced Biology; Oct2024, Vol. 8 Issue 10, p1-10, 10p
Publication Year :
2024

Abstract

Inner ear organoids play a crucial role in hearing research. In comparison to other animal models and 2D cell culture systems, inner ear organoids offer significant advantages for studying the mechanisms of inner ear development and exploring novel approaches to disease treatment. Inner ear organoids derived from human cells are more closely resemble normal human organs in development and function. The 3D culture system of the inner ear organoid enhances cell–cell interactions and mimics the internal environment. In this review, the progress and limitations of organoid culture methods derived from tissue‐specific progenitors and pluripotent stem cells (PSCs) are summarized, which may offer new insights into generating organoids that closely resemble the inner ear in terms of morphology and function. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
27010198
Volume :
8
Issue :
10
Database :
Complementary Index
Journal :
Advanced Biology
Publication Type :
Academic Journal
Accession number :
180231293
Full Text :
https://doi.org/10.1002/adbi.202400223