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Recent Progress in Generation of Inner Ear Organoid.
- Source :
- Advanced Biology; Oct2024, Vol. 8 Issue 10, p1-10, 10p
- Publication Year :
- 2024
-
Abstract
- Inner ear organoids play a crucial role in hearing research. In comparison to other animal models and 2D cell culture systems, inner ear organoids offer significant advantages for studying the mechanisms of inner ear development and exploring novel approaches to disease treatment. Inner ear organoids derived from human cells are more closely resemble normal human organs in development and function. The 3D culture system of the inner ear organoid enhances cell–cell interactions and mimics the internal environment. In this review, the progress and limitations of organoid culture methods derived from tissue‐specific progenitors and pluripotent stem cells (PSCs) are summarized, which may offer new insights into generating organoids that closely resemble the inner ear in terms of morphology and function. [ABSTRACT FROM AUTHOR]
- Subjects :
- ORGANS (Anatomy)
PLURIPOTENT stem cells
HAIR cells
MORPHOGENESIS
STEM cells
INNER ear
Subjects
Details
- Language :
- English
- ISSN :
- 27010198
- Volume :
- 8
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Advanced Biology
- Publication Type :
- Academic Journal
- Accession number :
- 180231293
- Full Text :
- https://doi.org/10.1002/adbi.202400223