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Privacy-friendly evaluation of patient data with secure multiparty computation in a European pilot study.
- Source :
- NPJ Digital Medicine; 10/14/2024, Vol. 7 Issue 1, p1-12, 12p
- Publication Year :
- 2024
-
Abstract
- In multicentric studies, data sharing between institutions might negatively impact patient privacy or data security. An alternative is federated analysis by secure multiparty computation. This pilot study demonstrates an architecture and implementation addressing both technical challenges and legal difficulties in the particularly demanding setting of clinical research on cancer patients within the strict European regulation on patient privacy and data protection: 24 patients from LMU University Hospital in Munich, Germany, and 24 patients from Policlinico Universitario Fondazione Agostino Gemelli, Rome, Italy, were treated for adrenal gland metastasis with typically 40 Gy in 3 or 5 fractions of online-adaptive radiotherapy guided by real-time MR. High local control (21% complete remission, 27% partial remission, 40% stable disease) and low toxicity (73% reporting no toxicity) were observed. Median overall survival was 19 months. Federated analysis was found to improve clinical science through privacy-friendly evaluation of patient data in the European health data space. [ABSTRACT FROM AUTHOR]
- Subjects :
- DATA security
STATISTICAL power analysis
MEDICAL informatics
RESEARCH funding
ACADEMIC medical centers
PRIVACY
CLINICAL medicine research
PILOT projects
PATHOLOGIC complete response
SCIENTIFIC observation
CANCER patients
TREATMENT effectiveness
DESCRIPTIVE statistics
CHI-squared test
METASTASIS
KAPLAN-Meier estimator
LONGITUDINAL method
ADRENAL tumors
CONFIDENCE intervals
RADIATION doses
MEDICAL ethics
GOVERNMENT regulation
Subjects
Details
- Language :
- English
- ISSN :
- 23986352
- Volume :
- 7
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- NPJ Digital Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 180236106
- Full Text :
- https://doi.org/10.1038/s41746-024-01293-4