Liberal or Adhere to Recommendations for Prothrombin Complex Concentrate Management in Major Bleeding Following Trauma:A Multicenter Retrospective Study.

The article discusses a clinical trial, NCT06627218, focusing on the management of major bleeding following trauma using Prothrombin Complex Concentrate (PCC). The study aims to evaluate the efficacy and safety of PCC in treating traumatic bleeding, as well as adherence to recommendations for its use. The trial is currently recruiting participants in China, with a primary completion date set for December 31, 2025. The study seeks to address the controversy surrounding the use of PCC in trauma management and the lack of clear indications for its use. [Extracted from the article]