New Cell Biology Findings from China Agricultural University Described [The Dose-dependent Dual Effects of Alpha-ketoglutarate (Akg) On Cumulus Oocyte Complexes During In Vitro Maturation].

Researchers from China Agricultural University have discovered the dual effects of Alpha-Ketoglutarate (AKG) on cumulus oocyte complexes (COCs) during in vitro maturation (IVM). At an appropriate concentration of 30 mu M, AKG has beneficial effects on IVM, improving cumulus expansion, oocyte quality, and embryo development. However, a high concentration of AKG (750 mu M) can have adverse effects on IVM, suppressing cumulus expansion and reducing oocyte quality. This study provides valuable insights into the variable effects of AKG on reproductive physiology. [Extracted from the article]