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The Functions of Cytokines in the Cardiac Immunopathogenesis of Chagas Disease.

Authors :
de Alba-Alvarado, Mariana Citlalli
Cabrera-Bravo, Margarita
Zenteno, Edgar
Salazar-Schetino, Paz María
Bucio-Torres, Martha Irene
Source :
Pathogens; Oct2024, Vol. 13 Issue 10, p870, 16p
Publication Year :
2024

Abstract

Chagas disease is a complex zoonosis. Clinically, it presents in two distinct phases, acute and chronic. The ability of patients to respond to Trypanosoma cruzi infection depends on the balance between inflammatory and anti-inflammatory responses, in which cytokines play a key regulatory role. In this review, we discuss the role of cytokines in regulating the host response and as mediators of cardiac injury by inducing profibrotic alterations. The importance of characterizing cytokine profiles as biomarkers of the evolution of cardiac damage in T.-cruzi-infected individuals is also emphasized. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20760817
Volume :
13
Issue :
10
Database :
Complementary Index
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
180523721
Full Text :
https://doi.org/10.3390/pathogens13100870