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The Functions of Cytokines in the Cardiac Immunopathogenesis of Chagas Disease.
- Source :
- Pathogens; Oct2024, Vol. 13 Issue 10, p870, 16p
- Publication Year :
- 2024
-
Abstract
- Chagas disease is a complex zoonosis. Clinically, it presents in two distinct phases, acute and chronic. The ability of patients to respond to Trypanosoma cruzi infection depends on the balance between inflammatory and anti-inflammatory responses, in which cytokines play a key regulatory role. In this review, we discuss the role of cytokines in regulating the host response and as mediators of cardiac injury by inducing profibrotic alterations. The importance of characterizing cytokine profiles as biomarkers of the evolution of cardiac damage in T.-cruzi-infected individuals is also emphasized. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHAGAS' disease
TRYPANOSOMA cruzi
HEART injuries
ZOONOSES
INFLAMMATION
Subjects
Details
- Language :
- English
- ISSN :
- 20760817
- Volume :
- 13
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 180523721
- Full Text :
- https://doi.org/10.3390/pathogens13100870