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Theoretical Model for In Vivo Induction of Chemotherapy Sensitization Using miRNA Packaged in Distinct Layered Liposomes.

Authors :
Cipu, Ruxandra-Ioana
Stănişteanu, Mihai-Laurențiu
Andrei, Mihaela-Aurelia
Banciu, Daniel Dumitru
Banciu, Adela
Source :
Journal of Functional Biomaterials; Oct2024, Vol. 15 Issue 10, p298, 15p
Publication Year :
2024

Abstract

Resistance to chemotherapy is a problem of major social and economic importance, when looking at factors like the decrease in life expectancy, the associated therapeutic costs, and a significant number of cancers that resist current chemotherapy. The development of chemotherapeutics for all theoretically possible tumor variants is an approach that requires unreasonable resources. We propose a theoretical model that serves the purpose of overcoming resistance to chemotherapeutic agents used in cancer therapy. The model describes a gene delivery system based on liposomes, which are optically guided to the tumor's location. The main aim of the gene delivery system is inhibiting the activity of enzymes involved in drug metabolism, hence offering the opportunity to use inexpensive chemotherapeutics that are already on the market. This model will reduce the costs of chemotherapy and will assure a positive outcome for patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20794983
Volume :
15
Issue :
10
Database :
Complementary Index
Journal :
Journal of Functional Biomaterials
Publication Type :
Academic Journal
Accession number :
180523834
Full Text :
https://doi.org/10.3390/jfb15100298