Research on biosafety risk management of laboratory animals in universities.

[Objective] Laboratory animal centers in colleges and universities are crucial for production, teaching, experimentation, and technical services involving laboratory animals. Biosafety management is an important part of their standardized operation and safety management. The Biosafety Law has highlighted the importance of biosafety and introduced new requirements for managing laboratory animals in universities. Establishing a systematic biosafety risk management framework is essential to prevent public health impacts related to biosafety and ensure effective management and operation. Comprehensive and systematic implementation of biosafety management in university laboratory animal centers is vital for the standardized management of facilities, the health and safety of staff and students, and the advancement of scientific research. [Methods] We evaluated the major biosafety hazards, classified as "internal factors" and "external factors", throughout the whole experimental process. Corresponding solutions were proposed. Considering the complexity of hazards within laboratory animal facilities, we clearly identified the biosafety hazards one by one and summarized them to obtain more effective and distinct measures. [Results] Using the Institute of Laboratory Animal Science of Jinan University as a case study, we explored effective strategies for managing biosafety in animal public service platforms, such as qualified animal experimental design, standardized facility management, strict environmental and animal monitoring, frequently disinfecting facilities, periodic waste disposal, effective pest control, and veterinary supervision. Specifically, they include: 1 Ensuring research projects are reviewed and approved by the Institutional Animal Care and Use Committee of Jinan University, adhering to the welfare and ethical principles of laboratory animals. 2 Implementing rigorous regulations for material types and delivery methods to maintain sterility. 3 Establishing different entry requirements and admission procedures for various personnel, with comprehensive training for experimental staff. 4 Daily checks of physical parameters of environmental facilities to ensure stable conditions. 5 Following the Biological Safety Law for treating wastewater, exhaust gas, and other waste materials. 6 Using at least two types of disinfectants to ensure effectiveness and prevent drug resistance, with clear guidelines for disinfection scope and methods. 7 Preventing and controlling biological vectors such as mosquitoes, flies, mice, and cockroaches through disinfection and sterilization. 8 Implementing isolation and quarantine, observation and treatment, anatomical sampling, and ensuring animal safety within the facility. [Conclusions] Universities should strictly implement the safety management responsibility system, investigate biological safety hazards, and determine effective responses to ensure the safe and effective operation of animal centers. [ABSTRACT FROM AUTHOR]