Intrinsic Diversity in Primary Cilia Revealed Through Spatial Proteomics.

The article discusses the intrinsic diversity in primary cilia, which are filamentous protrusions on human cells. It highlights the importance of studying ciliopathies, hereditary diseases linked to cilia dysfunction, to understand the tissue-specific roles of cilia. The research utilizes spatial proteomics to identify cell-type specific functions of ciliary proteins, revealing that protein trafficking plays a significant role in the functional tuning of individual cilia. The findings suggest that cilia act as dynamic sensory organelles, allowing cells to sense and integrate diverse signals. The study introduces new avenues for basic and clinical research on cilia and ciliopathies. [Extracted from the article]