An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs.

The article discusses the development of a platform for discovering and testing drugs to combat Plasmodium falciparum malaria transmission. The platform involves using transgenic parasites to create an in vitro screening assay and a preclinical in vivo transmission model in humanized mice. This research aims to address the challenges in identifying effective drugs against the mature stage V gametocytes responsible for transmitting the disease. The study has not yet undergone peer review and provides valuable insights into potential treatments for malaria. [Extracted from the article]