FGF2 promotes the expansion of parietal mesothelial progenitor pools and inhibits BMP4-mediated smooth muscle cell differentiation.

The article delves into the function of FGF2 in expanding parietal mesothelial progenitor pools and inhibiting BMP4-mediated smooth muscle cell differentiation. By culturing WT1+ MPCs from pig and mouse parietal thorax, researchers found that FGF2 promotes progenitor pool expansion, while BMP4 facilitates differentiation into SMCs. The study also highlights the importance of the Wnt activator CHIR99021 in MPC maturation to CALB2+ mesothelial cells, offering insights into mesothelioma diagnosis and treatment. The research underscores the significance of understanding mesothelial cell behaviors and signaling pathways for potential therapeutic advancements. [Extracted from the article]