FORMULATION AND EVALUATION OF FLURBIPROFEN AND BETAMETHASONE NANOGEL FOR ANTI-ARTHRITIC THERAPY.

In order to effectively treat arthritis, this study formulated and evaluated a nanogel containing flurbiprofen and betamethasone. Using ionic gelation technology, nanogels were created by fine-tuning a number of process parameters, such as the concentration of the polymer and cross-linker, as well as the stirring speed, stirring duration, and sonication time. The results demonstrated that the particle size and drug loading efficiency were enhanced as the concentrations of the polymer and cross-linker were increased; the ideal concentrations were 0.4% w/v polymer and 0.4% w/v cross-linker. Particle size was also shown to be greatly affected by stirring duration and speed; particles were found to be smaller while stirring for longer periods of time and faster speeds. Particle size was further reduced to 174.16 nm by sonication for 5 minutes, and the drug loading efficiency was an acceptable 72.02%. The enhanced formulation had a PDI, zeta potential, and particle size distribution that were advantageous, which improved stability and medicine encapsulation. Because it ensures a controlled release of the drug and improves patient outcomes, this nanogel system offers potential as a novel approach to providing anti-inflammatory drugs for the treatment of arthritis. [ABSTRACT FROM AUTHOR]