Study Findings on Cancer Are Outlined in Reports from Florida A&M University [In Silico Screening of 1,3,4-Thiadiazole Derivatives as Inhibitors of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)].

A recent study conducted at Florida A&M University focused on in silico screening of 1,3,4-thiadiazole derivatives as inhibitors of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) for potential anti-cancer therapies. The research aimed to identify lead compounds with VEGFR-2 inhibitory effects through a combination of pharmacophore modeling, molecular docking, ADMET studies, DFT analysis, and MD simulations. The study identified four compounds with promising lead requirements for inhibiting VEGFR-2 and suppressing angiogenesis in cancer therapy. This integrated approach provides valuable insights into the development of potential anti-cancer agents targeting VEGFR-2. [Extracted from the article]