Studies from University of Southern California (USC) Further Understanding of Proteins (Tdp43 and Huntingtin Exon-1 Undergo a Conformationally Specific Interaction That Strongly Alters the Fibril Formation of Both Proteins).

A recent study from the University of Southern California (USC) explores the interaction between proteins Tdp43 and Huntingtin Exon-1, which play roles in neurodegenerative diseases like Huntington's and ALS. The research suggests that these proteins undergo a conformationally specific interaction that alters their fibril formation, potentially contributing to disease pathology. The findings indicate that direct protein interaction may be responsible for the linked pathologies of both proteins. For more information, the study can be found in the Journal of Biological Chemistry. [Extracted from the article]