Impaired maturation of wild-type superoxide dismutase 1 associated with neurodegeneration in Parkinson disease brain and a novel murine model.

A study published in Drug Week discusses the impaired maturation of wild-type superoxide dismutase 1 (SOD1) in Parkinson's disease. The research explores the mechanisms behind the formation of SOD1 pathology in the brain and its impact on dopamine neuron health. The study introduces a novel mouse model, the SOCK mouse, to investigate the development of Parkinson-like SOD1 pathology and its effects on neurodegeneration. The findings suggest that correcting alterations to SOD1 post-translational modifications could be a potential drug target for Parkinson's disease. [Extracted from the article]