Duke University Researcher Adds New Data to Research in Lewy Body Disease (Mouse a-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases).

Researchers at Duke University have published a study on Lewy body disease, focusing on the aggregation and fibrillization of a-synuclein, which plays a crucial role in Parkinson's disease and multiple system atrophy. The study reveals the atomic structure of mouse a-synuclein fibrils, highlighting differences in structure, hydrophobicity, and immunological responses compared to human fibrils associated with Lewy body diseases. These findings offer insights into the pathogenicity of a-synuclein and suggest a reevaluation of the use of mouse a-synuclein fibrils in diagnostic and therapeutic research. [Extracted from the article]