Pharmacometrics in obstetrics and maternal–fetal medicine research: Bridging gaps in maternal and fetal pharmacology.

The article discusses the underutilization of pharmacometrics in obstetrics and maternal-fetal medicine research, despite the widespread use of medications during pregnancy. It highlights the importance of leveraging mathematical models like PBPK and PopPK approaches to predict maternal and fetal drug exposure, optimize therapeutic regimens, and address drug safety concerns. The text also emphasizes the need for advanced modeling approaches to improve drug dosing, efficacy, and safety profiles during pregnancy, as well as the challenges and barriers hindering the implementation of pharmacometrics in obstetrics. Overall, the article underscores the potential of pharmacometrics to enhance personalized drug therapy for pregnant women and improve outcomes for both mother and baby. [Extracted from the article]