Back to Search Start Over

Grid Efferocytosis via Near‐Field Electrostatic Printing Rectifies Skin Immunity.

Authors :
Li, Minxiong
Li, Xiaoxiao
Wang, Juan
Xia, Wenzheng
Bao, Luhan
Huang, Xin
Mao, Jiayi
Zhao, Yun
Li, Qingfeng
Cui, Wenguo
Zan, Tao
Source :
Advanced Functional Materials; 12/2/2024, Vol. 34 Issue 49, p1-16, 16p
Publication Year :
2024

Abstract

Efferocytosis, by phagocytosing and processing apoptotic cells in injured skin, directly influences the immune microenvironment. However, the comprehensive widespread inflammation and disrupted efferocytosis in injured skin cannot be effectively halted. Herein, "Grid Efferocytosis" strategy within injury site is proposed, which segments the inflammation regulatory into grid microdomains, and further rectifies intra‐grid immune microenvironment to accelerate tissue repair. GelMA/PLA/Laponite gridded fiber membranes (GPL) are custom‐designed via near‐field electrostatic printing, and then coated with HAMA‐PBA/EGCG hydrogel by photo‐crosslinking and dynamic borate bonding to form a composite fiber membrane (GPL‐E). Gridded modulation via GPL‐E confines the entire chaotic inflammatory microenvironment into controllable microinflammatory niches. Leveraging the hydrogel coating and boronic ester bond dissociation induced by microenvironmental glucose and reactive oxygen species, GPL‐E achieves dynamic anti‐glucose and anti‐oxidation within microdomains, reconstructing macrophage efferocytosis. Notably, the "grid efferocytosis" recruits repair cells into the grid by magnesium ion release triggered by Laponite exposure on fibers, and enhances endothelial cell vascularization by ≈2.5‐fold. In a mouse diabetic ischemic flap model, implantation of grid GPL‐E maintains flap‐to‐base fusion, attenuates inflammatory infiltration & spread, and improves blood perfusion for flap survival. This study demonstrates that "Grid Efferocytosis" rectifies the immune microenvironment, fostering tissue repair and regeneration. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1616301X
Volume :
34
Issue :
49
Database :
Complementary Index
Journal :
Advanced Functional Materials
Publication Type :
Academic Journal
Accession number :
181624895
Full Text :
https://doi.org/10.1002/adfm.202402713