ADVERSE EFFECTS OF ORAL ADMINISTRATION OF BISPHENOL A-INDUCED TOXICITY ON ADULT MALE RAT LIVER AND TESTIS WITH THE PROTECTIVE ROLES OF HERBAL TEAS.

Bisphenol A (BPA) is a monomer widely used in our living environment to manufacture many chemical products. Mammalian cells are exposed to it at high levels, which has toxic and estrogenic consequences. Moreover, BPA exposure during prenatal and neonatal development results in defects in the male and female reproductive systems, abnormal meiotic development in fetal oocytes, and pregnancy complications. The aim of the current study was to study the adverse effects of the oral administration of BPA on the liver and testis of adult male rats with the protective roles of herbal teas. A comparative study was conducted on 40 adult male Wistar rats (six weeks old, weighing 100-120 g). Groups were coded as RT/BPA, GT/BPA, and BT/BPA, for red, green, and blue herbal teas, respectively. Several evaluations such as weights, hepatic enzyme markers, lipid profile, and oxidative nitrosative stress for the liver and testis were conducted. Results indicated that exposure to BPA significantly increased oxidative nitrosative stress and damaged the hepatic tissue on the liver and testis. The ALT GT/BPA group detected the highest values for AST (61.87 mU/mL), ALP (2.48 mU/mL), LDH (1153.11 U/L), and GGT (49.72 U/L); RT/BPA group detected the lowest values for AST (58.71 mU/mL), ALP (1.51 mU/mL), and GGT (21.12 U/L). Similarly, the RT/BPA and BT/BPA groups were detected (4.11 and 4.12 mg/100 mL) for creatinine levels as compared to the vehicle control group. While rats in the BT/BPA and GT/BPA groups showed similar values to the vehicle group (45.02 and 118.28 mg/dI) for HDL and TC quantities, respectively. The present research established the protective role of herbal teas due to the antioxidant properties, especially of green tea, which preserved GPx value (88.22 nmol/mg), testosterone (1.80 ng/mL); and red tea, which preserved CAT value (101.18 U/mg); while blue tea preserved MDA and SOD values (0.81 nmol/mg and 7.18 U/mg), respectively. BPA oral administration with herbal teas reduced toxicity on the liver and testis due to free radical scavenging effects. [ABSTRACT FROM AUTHOR]