Antiageing properties of macrofungi extracts from Hericium erinaceus, Ganoderma lucidum, Coprinus comatus.

Introduction: Mushrooms are rich in bioactive compounds with potential antiageing properties. This study focuses on three species: Hericium erinaceus, Ganoderma lucidum, and Coprinus comatus. Objective: To evaluate the antioxidant and anti-tyrosinase activities of these mushrooms and assess the toxicity of their extracts on aquatic organisms. Methods: Antioxidant activities were measured using ABTS, CUPRAC, and DPPH assays, while antityrosinase activity was assessed spectrophotometrically. Toxicity tests were conducted on Daphnia pulex, Chironomus aprilinus larvae, and Chaoborus sp. larvae, using ethanol and aqueous extracts. Results: Ganoderma lucidum showed the highest antioxidant (97.09% ABTS, 90.83% DPPH) and antityrosinase activities. Coprinus comatus ethanol extract exhibited the highest toxicity, causing 50% mortality in tested organisms within ~8 hours. Hericium erinaceus extracts were the least toxic, especially aqueous extracts, which showed no toxicity. Conclusion: Mushroom extracts, particularly Ganoderma lucidum, demonstrate strong antioxidant and anti-tyrosinase activities with low toxicity, making them promising candidates for antiageing applications. [ABSTRACT FROM AUTHOR]