Growth factor-enhanced matrix combined either with free connective tissue graft or with collagen membrane in the treatment of Miller class II gingival recession.

Purpose: The goal of the study was to examine the efficacy of collagen membrane or free connective tissue graft in conjunction with growth factor-enhanced matrix (GEM) for treating Miller class two gingival recession. Patients and methods: Twenty sites in 10 patients, with class II Miller gingival recession were allocated randomly to be treated by (GEM21s) with free connective tissue graft (group I) or GEM21s with collagen membrane (group II). Recession width, recession depth, height of keratinized tissue and digital measurements were recorded at baseline, 1, 3, and 6 months. Probing pocket depth, clinical attachment level, gingival thickness, and radiographic parameters were recorded at baseline and 6 months. Root coverage percentage were recorded 6 months postoperative and wound healing index were recorded at 1, 3, and 6 months postoperative. Results: Both groups showed significant improvement in all clinical parameters and increase in bone level was observed after 6 months compared to baseline measures. There was no statistically significant difference between both groups except for recession depth at 1 and 3 months after surgery and height of keratinized tissue at 1, 3, and 6 months in favor of group I. Radiographically there was a statistically significant difference (P ≤ 0.05) in amount of labial bone gain and bone density in favor of group I compared to group II. Conclusion: GEM21s combined either with free connective tissue graft or collagen membrane led to favorable gingival coverage and radiographical results with better results for free connective tissue graft with GEM21s. [ABSTRACT FROM AUTHOR]