Cancer Histone Mutations Impact Binding and DNA Repair Processes, Leading to Increased Mutagenesis.

The article from Cancer Weekly discusses how histone mutations impact binding and DNA repair processes, leading to increased mutagenesis in cancer patients. Histones play a crucial role in regulating the accessibility and compaction of eukaryotic genomes, affecting DNA replication, repair, and expression. The study gathered data from over 12,000 cancer patients and found that histone mutations occurred in about 16% of them, with specific cancer types showing higher rates. The research identified potential cancer driver mutations in histone genes, shedding light on the oncogenic potential of these mutations. [Extracted from the article]