New Life Science Findings from Northeastern University Described (Role of Ryanodine Receptor Cooperativity In Ca2+-wave-mediated Triggered Activity In Cardiomyocytes).

A recent study from Northeastern University in Boston, Massachusetts, explores the role of Ryanodine Receptor cooperativity in Ca2+-wave-mediated triggered activity in cardiomyocytes. The research addresses challenges in modeling Ca2+ waves and suggests that targeting RyR cooperativity could be a promising strategy for treating cardiac arrhythmias. The study, published in the Journal of Physiology-london, highlights the importance of a physiologically realistic model with a Hill coefficient in the RyR gating function to generate organized Ca2+ waves and replicate experimentally observed manifestations of triggered activity. [Extracted from the article]