Findings from Department of Chemistry Update Understanding of Diabetes Research (Insights Into the Role of Potent Thiadiazole Based Schiff Base Derivatives In Targeting Type-ii Diabetes: a Combine In-vitro and In-silico Approaches).

Researchers in Abbottabad, Pakistan, have developed a novel series of thiadiazole-based Schiff base analogues to target enzymes involved in hyperglycemia, such as alpha-amylase and alpha-glucosidase. These analogues showed promising inhibitory activities compared to a known drug, acarbose. Compound (20) with a tri-fluoromethyl group demonstrated the most effective inhibitory activity. The study also included molecular docking and ADME analysis to explore drug likeness and toxicity. For more information, readers can contact the Department of Chemistry at Abbottabad University of Science and Technology in Pakistan. [Extracted from the article]