New Ubiquitins Study Findings Have Been Reported by Researchers at University of Coruna (Beyond Destruction: Emerging Roles of the E3 Ubiquitin Ligase Hakai).

Researchers at the University of Coruna have reported new findings on the Hakai protein, identifying it as an E3 ubiquitin ligase involved in the degradation of E-cadherin complex, leading to epithelial-to-mesenchymal transition. Recent research has also highlighted Hakai's noncanonical role in the N-6-methyladenosine writer complex, impacting RNA methylation and its potential as a cancer biomarker. The development of a small-molecule inhibitor targeting Hakai's atypical substrate binding domain shows promise for potential clinical applications. [Extracted from the article]