Studies from Indiana University School of Medicine in the Area of Hyperhomocysteinemia Published (Hyperhomocysteinemia-induced VCID results in visual deficits, reduced neuroinflammation and vascular alterations in the retina).

A recent study conducted at Indiana University School of Medicine focused on hyperhomocysteinemia-induced VCID and its effects on visual deficits, neuroinflammation, and vascular alterations in the retina. The research aimed to identify the impact of cerebral small vessel disease on visual sensitivity, cognition, retinal glial and vascular cells, and gene expression changes. The findings revealed that hyperhomocysteinemia led to specific visual changes, decreased vascular volume, altered interaction of microglia with the vasculature, and downregulation of inflammatory and vascular genes. This study sheds light on retinal changes associated with cerebral small vessel disease and emphasizes the importance of considering vision-related cognitive testing in such models. [Extracted from the article]