Analysis of influencing factors for acute exacerbation of chronic obstructive pulmonary disease in Yunnan Province: A retrospective cohort study.

Objective To explore the incidence, time of occurrence and influencing factors of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in stable chronic obstructive pulmonary disease (COPD) patients within one year. Methods Retrospectively collected information on COPD case home page visits in Yunnan Province from 2016 to 2022, establishing a longitudinal observation cohort based on patients' names and ID numbers. The incidence rate, time of occurrence and average number of AECOPD within one year of COPD were calculated, and the relationship between patients' exposure factors and the number of AECOPD within one year was analyzed by using multivariate linear regression, and the exposure factors affecting AECOPD within one year of COPD patients were analyzed by using Cox regression. Results The mean age of 405 428 COPD patients was (70. 75 ' 10.95) years, the mean number of comorbidities was 1.14 ± 1.15, the incidence of AECOPD within one year was 17.55%, the mean duration of occurrence was (4.58 ± 3.64) months, and the mean number of AECOPD per patient was 0.27. The regression results showed that gender (HR = 1.473, 95% CI: 1.446-1.500), age (HR=1.011, 95% CI: 1.010-1.012), number of comorbidities (HR=1. 083, 95% CI: 1.076-1.090), medical insurance type (HR=1.481, 95% CI: 1.394-1.574), and admission season (HR=1.115, 95% CI: 1.090-1.140) were the influencing factors for acute exacerbation in patients with COPD within one year. Conclusion The incidence of AECOPD in COPD patients in Yunnan Province within one year is 17.55%. We should start from various risk factors and focus on male, elderly, patients with multifile comorbidities, those admitted in spring and winter seasons, and non-resident medical insurance patients. Take corresponding preventive measures and strengthen the management of AECOPD. [ABSTRACT FROM AUTHOR]