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From rheumatic fever to Libman–Sacks endocarditis: is there any possible pathogenetic link?
- Source :
- Lupus; 2005, Vol. 14 Issue 9, p697-701, 5p
- Publication Year :
- 2005
-
Abstract
- The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of the disease; 3) cross reacting antibodies between the pathogen and self molecules; 4) endothelial cell activation in the 'crime-area' i.e., the valves; 5) some of the patients with RF have circulating antiphospholipid antibodies, while APS may be associated with streptococcal infection; and 6) recently, a cross-reactivity between antibodies directed to the streptococcal M-protein and its synthetic derivative in rheumatic fever (RF) and antibodies derived from APS patients targeting the beta-2-glycoprotein-I (β2GPI) and a β2GPI related synthetic peptide. In the current paper, we summarize the possible links between the heart involvement in RF and APS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09612033
- Volume :
- 14
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Lupus
- Publication Type :
- Academic Journal
- Accession number :
- 18339153
- Full Text :
- https://doi.org/10.1191/0961203305lu2203oa