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Interleukin-4 Induces In Vitro Migration in Naive B Cells Through Direct Mechanisms.
- Source :
- Scandinavian Journal of Immunology; Oct1994, Vol. 40 Issue 4, p429-436, 8p, 1 Diagram, 2 Charts, 4 Graphs
- Publication Year :
- 1994
-
Abstract
- Interleukin-4 (IL-4) mediated locomotor responses by murine B cells <em>in vitro</em> were examined in this paper. The IL-4 induced migration was found to act directly on purified, splenic B cells, without involvement of secondary mediators. It appeared that only a subpopulation of B cells was able to respond in migration assays. Flowcytometric analysis showed that the migrating cells had the characteristics of naive B cells: I-A<superscript>lo</superscript>, J11d<superscript>hi</superscript>, IgD<superscript>hi</superscript>. They also displayed high expression of the adhesion molecule L-selectin and made predominantly IgM antibodies. This is contrary to what has previously been observed regarding motile responses to chemotactic factors by T cells, which mostly affect memory or activated T cells. However, this is in accordance with other studies indicating that IL-4 is a cytokine that exerts its effect mainly on resting B cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTERLEUKIN-4
B cells
IMMUNOGLOBULINS
T cells
MEMORY
Subjects
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 40
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 18721790
- Full Text :
- https://doi.org/10.1111/j.1365-3083.1994.tb03485.x