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Interleukin-10 Suppresses the Development of Collagen Type II-Induced Arthritis and Ameliorates Sustained Arthritis in Rats.

Interleukin-10 Suppresses the Development of Collagen Type II-Induced Arthritis and Ameliorates Sustained Arthritis in Rats.

Authors :
Persson, S.
Mikulowska, A.
Narula, S.
O'Garra, A.
Holmdahl, R.
Source :
Scandinavian Journal of Immunology; Dec1996, Vol. 44 Issue 6, p607-614, 8p, 2 Charts, 4 Graphs
Publication Year :
1996

Abstract

The collagen-induced arthritis model in DA rats induced with homologous rat type II collagen was chosen to determine the therapeutic capacity and effects on autoimmunity by IL-10. Systemic IL-10 treatment (100 or 10 µg/day) with mini-osmotic pumps during the periods of arthritis onset (days 12-20 after immunization) decreased the frequency of arthritis and delayed the onset and reduced the severity of arthritis in the few rats that eventually developed arthritis. Concomitantly, levels of autoantibodies to CII were reduced. To test the activity on established arthritis, IL-10 was administered subcutaneously in the paws. This treatment reduced the swelling but did not block the arthritis process. The effective treatment required 100µg of IL-10 every 12th hour while 50 µg of IL-10 had little effect, although a tendency of reduced paw swelling was observed. Surprisingly, therapeutic IL-10 treatment led to higher serum levels of autoantibodies to CII. The highest doses of IL-10 (100 µg) did not show any apparent toxic effects when given locally or systematically. Taken together, this study suggests that IL-10 is a candidate for treatment of rheumatoid arthritis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03009475
Volume :
44
Issue :
6
Database :
Complementary Index
Journal :
Scandinavian Journal of Immunology
Publication Type :
Academic Journal
Accession number :
18726894
Full Text :
https://doi.org/10.1046/j.1365-3083.1996.d01-355.x