Warfarin was not more effective than aspirin and increased adverse events in symptomatic intracranial arterial stenosis.

The article discusses whether aspirin is effective and safe for primary prevention of cardiovascular disease in women. Aspirin and warfarin did not differ for the primary composite endpoint or for death from vascular or non-vascular causes. Warfarin was associated with higher rates of all cause death, major hemorrhage, and myocardial infarction or sudden deaths than aspirin. In patients with symptomatic intracranial arterial stenosis, warfarin was not more effective than aspirin and increased the rates of all cause death, major haemorrhage, and myocardial infarction or sudden death.