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Comparison of two single-day regimens of triclabendazole for the treatment of human pulmonary paragonimiasis
- Source :
- Transactions of the Royal Society of Tropical Medicine & Hygiene; Jul2003, Vol. 97 Issue 4, p451-454, 4p
- Publication Year :
- 2003
-
Abstract
- A well-tolerated single-day treatment regimen is required for the community-based treatment of pulmonary paragonimiasis. To identify an optimal single-day treatment regimen, an open clinical trial was performed to compare the efficacy of 2 single-day regimens of triclabendazole. From 1991 to 1993, a total of 154 Ecuadorian patients were allocated to receive either a single dose or 2 doses of 10 mg/kg triclabendazole. Treatment with both regimens was associated with a rapid parasitological response (determined by clearance of Paragonimus eggs from sputum), resolution of most clinical symptoms and radiological signs, and only mild adverse effects. At 3 months after treatment, the cure rate (clearance of eggs from sputum) was 90.9% in the 2-dose group and 84.4% in the single-dose group. Re-treatment with a second 2-dose regimen was curative in all remaining patients by 1 year of follow-up. Our findings show that both single-day treatment regimens of triclabendazole were highly effective in the treatment of pulmonary paragonimiasis and suggest that patients should be re-examined at 3 months to determine the need for repeat treatment. [Copyright &y& Elsevier]
- Subjects :
- PARAGONIMIASIS
MEDICAL research
CLINICAL trials
HELMINTHIASIS
Subjects
Details
- Language :
- English
- ISSN :
- 00359203
- Volume :
- 97
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Transactions of the Royal Society of Tropical Medicine & Hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 18934896
- Full Text :
- https://doi.org/10.1016/S0035-9203(03)90088-5