Back to Search Start Over

K+ channel expression in prostate epithelium and its implications in men with chronic prostatitis.

Authors :
Chao-Zhao Liang
Qing-Kui Guo
Zong-Yao Hao
Sen Yang
De-Bin Wang
Li-Xin Wu
Cheng Liu
Ke-Xiao Wang
Xue-Jun Zhang
Source :
BJU International; Jan2006, Vol. 97 Issue 1, p190-192, 3p, 1 Color Photograph
Publication Year :
2006

Abstract

OBJECTIVE To investigate the effect of the Kv1.3 K<superscript>+</superscript> channel on the pathogenesis of chronic prostatitis. MATERIALS AND METHODS The expression of the Kv1.3 K<superscript>+</superscript> channel in prostatic epithelia was detected using streptavidin/peroxidase immunohistochemistry in tissue samples from 75 men with benign prostatic hyperplasia, including 42 with and 33 without chronic inflammation. All of the men were sampled in our hospital between January 2000 and December 2003. RESULTS There was strong and moderate immunostaining in 14 of the prostatic epithelial specimens with inflammation and in 21 from patients without inflammation, compared to 28 and 12 with low staining, respectively (chi-squared, P < 0.05). CONCLUSIONS The expression of the Kv1.3 K<superscript>+</superscript>channel was lower in prostatic epithelial cells from patients with chronic inflammation than from those without. Opening the Kv1.3 K<superscript>+</superscript> channel could promote the efflux of K<superscript>+</superscript> from the cells, causing an increase in [K<superscript>+</superscript>] in the prostate cavity. The increase in [K<superscript>+</superscript>] can then infiltrate the stroma through the epithelial gap, exciting the nerve fibres and causing pain and other clinical symptoms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14644096
Volume :
97
Issue :
1
Database :
Complementary Index
Journal :
BJU International
Publication Type :
Academic Journal
Accession number :
19050594
Full Text :
https://doi.org/10.1111/j.1464-410X.2006.05874.x